(1990) Abnormally high expression of
proteasomes in human leukemic cells.
Kloetzel, "Generation of major histocompatibility complex class I antigens: functional interplay between
proteasomes and TPPII," Nature Immunology, vol.
Proteasomes activate NF-[kappa]B by the degradation of its inhibitor and cause an increase in cytokine production in response to surgical stress [8].
The PA28-dependent regulation of OPN expression was stimulated by high glucose and abrogated by synthetic peptides that block the binding of PA28 to 20S
proteasomes. Therefore, the findings of this study provide novel insights into the role of the ubiquitin
proteasome system (UPS) and specially the PA28 proteins, in regulating the microvascular injury in diabetes.
Proteasomes are protein complexes with a main function to regulate and degrade unnecessary or damaged proteins by proteolysis, while spliceosome is a complex molecular machine assembled from snRNPs and protein complexes.
DeMartino, "Intracellular localization of
proteasomes," International Journal of Biochemistry and Cell Biology, vol.
Different forms of
proteasomes are known in eukaryotes.
Schuman, "Activity-dependent dynamics and sequestration of
proteasomes in dendritic spines," Nature, vol.
It is suggested that AGE accumulation may arise from ineffective removal of oxidatively modified proteins by the cellular proteolytic systems, such as the
proteasomes [26].
Other topics include the programming of DNA methylation patterns, ubiquitin and
proteasomes in transcription, toward the single-hour high-quality genome, the regulation of glucose transporter translocation in health and diabetes, the structural basis for the control of eukaryotic protein kinases, and pluripotency and nuclear reprogramming.
Abhimany Garg, Chief of Nutrition and Metabolic Diseases and senior author of the study, said that in addition to providing a clue to the cause of JMP syndrome, the findings also tell researchers more about the role
proteasomes play in the immune response.