Structure and mechanism of brca1 brct domain recognition of phosphorylated
bach1 with implications for cancer.
In mammals, this family includes six members, Nrf1, (26) Nrf2, (27) Nrf3, (28) nuclear factor erythroid 2 (NF-E2) p45 subunit, (29,30) BTB and CNC homolog 1 (
Bach1), (31) and Bach2.
In fact, hepatic HMOX1 has been widely studied, and a wealth of scientific evidence has shown that HMOX1, mainly through a mammalian transcription factor
Bach1, can protect cells from oxidative stress and apoptosis [23-26].
Tyrrell, "The role of
Bach1 in ultraviolet A-mediated human heme oxygenase 1 regulation in human skin fibroblasts," Free Radical Biology & Medicine, vol.
Sodhi et al., "Crosstalk between EET and HO-1 downregulates
Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes," Prostaglandins and Other Lipid Mediators, vol.
For instance, repression of BTB domain and CNC homolog (
Bach1), a nuclear inhibitor of Nrf2, in combination with traditional Nrf2 activators, has shown promising results in neurodegenerative disease models for safely increasing the efficiency and biological activity of these agents [158].
In response to oxidative stress, regulatory proteins such as NRF1, NRF3 and
BACH1 bind to AREs and compete for binding with NRF2.
The let-7 microRNA enhances heme oxygenase-1 by suppressing
Bach1 and attenuates oxidant injury in human hepatocytes.
Overexpression of transcription factor
BACH1 in fetal Down syndrome brain.
Jaiswal, "Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of
Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression," Journal of Biological Chemistry, vol.