Dereplication

De`rep`li`ca´tion

(Biochem.) the process of testing samples of mixtures which are active in a screening process, so as to recognize and eliminate from consideration those active substances already studied; - a stage subsequent to the preliminary screening in the process of discovery of new pharmacologically active substances in mixtures of natural products; - also called counterscreening. See screening.

Webster's Revised Unabridged Dictionary, published 1913 by G. & C. Merriam Co.

References in periodicals archive ?

After quality filtering and dereplication of identical sequences, 8,483 reads were retained from the water samples collected during vegetative stage and 7,348 reads were retained from samples collected during the reproductive stage.

Bacterial Community of the Rice Floodwater Using Cultivation-Independent Approaches

Wang, "Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry," Molecules, vol.

Analysis of Three Compounds in Flos Farfarae by Capillary Electrophoresis with Large-Volume Sample Stacking

Dereplication is a process used in recognising and eliminating the active substances that have already been studied in the early stage of the screening process [4].

Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach

Crotti, "Electrospray ionization tandem mass spectrometry as a tool for the structural elucidation and dereplication of natural products: an overview," in Tandem mass spectrometry: applications and principles, J.

Differentiation between 3,4- and 4,15-Epoxyeudesmanolides by Electrospray Ionization Tandem Mass Spectrometry

Methods: While exploring the bioactive secondary metabolites, a sensitive and reliable LC-MS based dereplication approach was applied to identify four compounds A-D from fungal extract.

Isolation and characterization of bioactive metabolites from Xylaria psidii, an endophytic fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells

UPLC-MS technique is very power full technique which help us in identifying compounds with satisfactory knowledge for efficient dereplication. It has several advantages over conventional HPLC-MS which includes quality of results, efficiency, speed, resolution, sensitivity, pressure limit, versatility of solvents used and column chemistry.

In-vitro Antitumor Activity and Metabolic Finger Printing of the Actinomycetes Isolated from Various Ecological Niches in Pakistan

Based on the microscopic and cultural characteristics, 54 different actinomycete isolates were selected after dereplication of 18 isolates.

Bioactive potential of actinomycetes from less explored ecosystems against Mycobacterium tuberculosis and other nonmycobacterial pathogens

Gamble et al., "Evolving strategies for the selection dereplication and prioritization of antitumor and HIV-inhibitory natural products extracts," in Bioassay Methods in Natural Product Research and Drug Development, L.

Cytotoxic activities of flavonoids from Centaurea scoparia

The MALDI Biotyper family of systems provides molecular detection, as well as taxonomical classification or dereplication of microorganisms such as bacteria, yeasts and fungi, using proteomic fingerprinting by high-throughput MALDI-TOF mass spectrometry.