organification


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or·gan·i·fi·ca·tion

(ōr-gan-i-fi-kā'shŭn),
The addition of inorganic iodine ot tyrosine residues in the thyroid by thyroid peroxidase.
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Iodine- containing compounds mainly inhibit thyroid hormone release and transiently inhibit organification. Lithium also inhibits thyroid hormone release and may inhibit thyroid hormone synthesis.
Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future
These include interference with enterohepatic circulation of thyroxine (17), competition with thyroid hormones for thyroid sulfotransferase enzymes (18), inhibition of thyroid peroxidase (19) and interference with thyroid hormone synthesis by inhibition of iodide uptake and organification (8).
Evaluation of effect of isoflavone on thyroid economy & autoimmunity in oophorectomised women: a randomised, double-blind, placebo-controlled trial
Because iodine uptake is low in this type of AIT, targeting the organification process with a thionamide would not be expected to have a significant effect.
Pharmacodynamic effect of iopanoic acid on free [T.sub.3] and [T.sub.4] levels in amiodarone-induced thyrotoxicosis
The process consists of the following five steps: iodine uptake by the cells of the follicle, organification, coupling, storage, and secretion.
Thyroid function test: a clinical lab perspective
Iodide organification defects are associated with mutations in the TPO or DUOX2 genes (22-25) and are characterized by a positive perchlorate discharge test.
Three mutations (p.Q36H, p.G418fsX482, and g.IVS 19-2A>C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect
Twelve patients (36%) were diagnosed with dyshormonogenesis, which consisted of an organification defect in all but one patient.
Use ultrasound to dx thyroid disorder: congenital hypothyroidism. (Clinical Rounds)
Lin, "High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect," The Journal of Clinical Endocrinology & Metabolism, vol.
Mutational Spectrum Analysis of Seven Genes Associated with Thyroid Dyshormonogenesis
Vulsma T, Gons MH, de Vijlder JJM, 1989, Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis, N Engl J Med 321(1):13-16, Wilber JF, Utiger RD, 1969, The effect of glucocorticoids on thyrotropin secretion, J Clin Invest 48(11):2096-2103.
Fetal thyroid function, birth weight, and in Utero exposure to fine particle air pollution: a birth cohort study
Trapping, organification, and storage of iodine are usually more prominent in functioning thyroid tissue than other organs.
False Positive Findings on I-131 WBS and SPECT/CT in Patients with History of Thyroid Cancer: Case Series
However, high thyroglobulin levels and goiter may be also caused by iodine organification defects, which have been detected in nearly 20% of the patients with transient CH (10).
Transient Congenital Hypothyroidism in Turkey: An Analysis on Frequency and Natural Course
It inhibits iodide transport and organification as well as increasing the efflux of iodide from the gland.
Study on thyroid status and oxidants in smokers and alcoholics

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