ADAMTSae4

(redirected from Aggrecanase-1)

ADAMTSae4

An ADAMTSs family enzyme encoded by ADAMTS4 on chromosome 1q21-q23, which cleaves aggrecan, the major proteoglycan of cartilage, the proteolytically active form of which may require removal of the prodomain by furin-like activity and part of the C-terminal spacer domain by other matrix metalloproteinases. ADAMTS4 is found mainly in brain, lung, heart, chondrocytes and in joint tissues from arthritic rats (and presumably arthritic patients). ADAMTS4 and ADAMs family members are upregulated in breast cancer.

References in periodicals archive ?

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis

Inoki et al., "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites," The Journal of Biological Chemistry, vol.

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

Okada, "Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)," Biochemical and Biophysical Research Communications, vol.

ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice

Yonezawa et al., "MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes," Arthritis Research & Therapy, vol.

Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis

Fujita et al., "Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-[kappa]B," The American Journal of Pathology, vol.

Follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.

Processing of pro-b-type natriuretic peptide: furin and corin as candidate convertases

Lentivirus-mediated knockdown of aggrecanase-1 and -2 promotes chondrocyte-engineered cartilage formation in vitro.

Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase2 on rat costochondral chondrocytes in vitro.

Delivery of the Sox9 gene promotes chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells in an in vitro model