BACE1

(redirected from ASP2)

BACE1

B-site amyloid precursor protein (APP) cleaving enzyme. An aspartic-acid protease encoded by BACE1 on chromosome 11q23.2.-q23.3, which is linked to the pathogenesis of Alzheimer's disease and the formation of myelin sheaths in peripheral nerve cells. BACE1 is a transmembrane aspartic protease (beta-secretase) found in the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. It cleaves amyloid precursor protein (APP) in the brain into amyloid beta peptide, a major component of the amyloid plaques of Alzheimer's disease (AD), the deposition of which is the central pathology in AD, for which BACE1 is potential therapeutic target.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Before the modernisation project, Davyhulme WwTW had two activated sludge plants running in parallel (ASP1 and ASP2, each dealing with half of the flows).
The wonders of waste: A 200 million [pounds sterling] investment at United Utilities' Davyhulme wastewater treatment works in Greater Manchester has put the site right at the forefront when it comes to sewage treatment
According to the assumption Asp2 and the message meaning rules, we can get:
An Improved Authentication and Key Agreement Scheme for Session Initial Protocol
For functional assays, the H2[K.sup.b]-restricted VNHRFTLV peptide from the amastigote surface protein 2 (ASP2) [18] was synthesized by GenScript USA Inc.
Tumor necrosis factor is a therapeutic target for immunological unbalance and cardiac abnormalities in chronic experimental Chagas' heart disease
Plaintiff had instituted this action in order to ascertain why the parties have come to this decision when the Agreement filed asP2 has been terminated illegally.
Double Speak Of Norway Exposed
(29) For the PCR, reaction mixtures consisted of GoTaq Colorless Master Mix (Promega), 50 pmol each of primer (Asp-1 5'CGGCCCTTAAATAGCCCGGTC-3' and Asp2 5'-ACCCCCCTGAGCCAGTCCG-3') (Sigma, St Louis, MO, USA), template DNA, and nuclease-free water.
Galactomannan assay and plasma protein electrophoresis findings in psittacine birds with Aspergillosis
129) that the Perfect Participle has two aspectual projections (ASP1/T2 and ASP2), in whose Spec positions appena may land, taking up correspondingly different interpretations.
Tense, aspect, and syntax (1)
The enzyme has N- and C-terminal domains that are separated by a deep cleft containing the active aspartate residues Asp34 and Asp2 16.
Macromolecular crystallography and structural biology databases at NIST
Diatoms were grown in the ASP2 medium of Provasoli et al.
Evaluation of the effects of extremely low frequency electromagnetic fields on movement in the marine diatom Amphora coffeaeformis

Medical browser ?
Full browser ?