rilpivirine

Kaviarasu, "Development and validation of RP-UPLC analytical method for simultaneous estimation of the emtricitabine, tenofovir disoproxil fumerate and rilpivirine and its pharmaceutical dosageform," International Research Journal of Pharmacy, vol.

Rilpivirine has been approved for the treatment of HIV-1 infection, in combination with other antiretroviral drugs, in treatment-naive adults, according to a statement by the Food and Drug Administration.

has entered into a license and collaboration agreement with Tibotec Pharmaceuticals for the development and commercialization of a once-daily, fixed-dose antiretroviral regimen containing Gilead's Truvada (emtricitabine and tenofovir disoproxil fumarate) and Tibotec's investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 (rilpivirine hydrochloride, 25 mg) for treatment-naive HIV-infected individuals.

Patients and their physicians can be further encouraged by the knowledge that there are several other compounds (such as the new NNRTI rilpivirine) that are advancing through clinical drug development and may soon be available in the clinic.

United Kingdom-based ViiV Healthcare is seeking approval from the US Food and Drug Administration (FDA) for the investigational, monthly, injectable, two-drug regimen of cabotegravir and rilpivirine to treat HIV, it was reported yesterday.

ViiV Healthcare (GSK) presented comprehensive 48-week data from the ATLAS pivotal phase III studies of the novel, investigational, long-acting regimen of cabotegravir and rilpivirine. These two studies met their primary endpoints, showing that the combination of ViiV Healthcare's cabotegravir and Janssen's (JNJ) rilpivirine, injected every four weeks, was non-inferior in maintaining viral suppression in adults infected with human immunodeficiency virus type-1 when compared to a standard of care, daily, oral three-drug regimen.

After a 20-week induction on daily oral cabotegravir plus abacavir-lamivudine, participants were randomized either to intramuscular long-acting cabotegravir plus rilpivirine at 4-week or 8-week intervals, or to continue with the oral therapy.

(20,34) The newer nonnucleosides etravirine and rilpivirine have better lipid profiles.

Emtricitabine and tenofovir alafenamide are from Gilead, while rilpivirine is from Janssen Sciences Ireland.

VIENNA -- Rilpivirine, an investigational non-nucleoside reverse transcriptase inhibitor for treating HIV, matched the efficacy of the benchmark agent in the class, efavirenz, and edged efavirenz for safety in a pair of phase III studies with more than 1,300 patients combined.

ENPNewswire-July 30, 2019--ViiV Healthcare submits regulatory application to European Medicines Agency for investigational cabotegravir to be used in combination with rilpivirine