(2) In addition, many of the current
anticonvulsants have various complications and serious side effects such as hepatotoxicity and agranulocytosis, (1, 3, 4) which necessitates new drugs with more suitable margins of safety and more tolerability.
George, "Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents,
anticonvulsants, lipid-lowering agents, psychotropic drugs," Seminars in Liver Disease, vol.
With a history of seizures, she also took several
anticonvulsants throughout her pregnancy.
Anticonvulsants also might increase resistance to pseudohypoparathyroidism and inhibit calcitonin secretion.
Our patient was given
anticonvulsants for her seizures, which may have resulted in the delay of her diagnosis.
Popp, Potential
anticonvulsants VI: Condensation of isatins with cyclohexanone and other cyclic ketones, J.
Several
anticonvulsants are used to prevent and treat mood episodes.
Nine out of 12 patients received antihypertensive agents to control the blood pressure, and 8 out of the 12 patients received
anticonvulsants to manage seizures.
In this study on the patients who were admitted to the emergency department of DEUH due to
anticonvulsant overdose, only blood carbamazepine, valproic acid, phenytoin and phenobarbital levels could be measured in the DEUH laboratories, serum levels of the other
anticonvulsants could not be measured.
While hypersensitivity drug reactions are well known, the hereditary component of AHS remains unfamiliar to physicians who prescribe
anticonvulsants, as demonstrated by our case.