In a series of patients with breast cancer receiving high-dose cyclophosphamide, cisplatin, and
BCNU followed by autologous HSCT, >30% decline in diffusing gas transfer was observed in 15-18 weeks following the chemotherapy (68).
Bortey et al., "A phase 3 trial of local chemotherapy with biodegradable carmustine (
BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma," Neuro-Oncology, vol.
The reported cooperative effects of MJ with other drugs are shown in Table 3: (1)
BCNU (carmustine), an alkylating nitrosourea agent with no cytotoxic effect on pancreatic carcinoma cell line MIA PaCa-2 in vitro combined with MJ showed enhanced cell death [170].
High-dose chemotherapy (
BCNU 300 mg/[m.sup.2], etoposide 200 mg/[m.sup.2], Ara-C 200 mg/[m.sup.2], melphalan 140 mg/[m.sup.2]) was given and autologous stem cell transplantation (ASCT) was performed.
Colvin et al., "The intracerebral distribution of
BCNU delivered by surgically implanted biodegradable polymers," Journal of Neurosurgery, vol.
investigated the delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea (
BCNU) to glioblastomas in rats with induced tumours with the help of FUS.
Burger et al., "A randomized comparison of intra-arterial versus intravenous
BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma," Journal of Neurosurgery, vol.
PB-100: a potent and selective inhibitor of human
BCNU resistant glioblastoma cell multiplication.