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(−)-endo-fenchol synthase

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(−)-endo-fenchol synthase
Identifiers
EC no.4.2.3.10
CAS no.117758-41-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme (−)-endo-Fenchol synthase (EC 4.2.3.10) catalyzes the chemical reaction

geranyl diphosphate + H2O (−)-endo-fenchol + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (−)-endo-fenchol-forming]. Other names in common use include (−)-endo-fenchol cyclase, and geranyl pyrophosphate:(−)-endo-fenchol cyclase. This enzyme participates in monoterpenoid biosynthesis.

References

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  • Croteau R, Miyazaki JH, Wheeler CJ (1989). "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(−)-endo-fenchol cyclase from fennel (Foeniculum vulgare)". Arch. Biochem. Biophys. 269 (2): 507–16. doi:10.1016/0003-9861(89)90134-3. PMID 2919880.
  • Croteau R, Satterwhite DM, Wheeler CJ, Felton NM (1988). "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (−)-endo-fenchol". J. Biol. Chem. 263 (30): 15449–53. doi:10.1016/S0021-9258(19)37609-4. PMID 3170591.