reserpine

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re·ser·pine

(rĭ-sûr′pēn′, -pĭn, rĕs′ər-pĭn, -pēn′, rĕz′-)

A drug, C₃₃H₄₀N₂O₉, isolated from the roots of certain species of rauwolfia and used as an antihypertensive.

[German Reserpin, from shortening and alteration of New Latin Rauvolfia serpentīna, species of snakeroot : rauwolfia + Late Latin serpentīna, feminine of serpentīnus, serpentine; see serpentine.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

reserpine

(ˈrɛsəpɪn)

(Pharmacology) an insoluble alkaloid, extracted from the roots of the plant Rauwolfia serpentina, used medicinally to lower blood pressure and as a sedative and tranquillizer. Its main adverse effect is mental depression. Formula: C33H40N2O9

[C20: from German Reserpin, probably from the New Latin name of the plant]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

res•er•pine

(rəˈsɜr pɪn, -pin)

n.

an alkaloid, C₃₃H₄₀N₂O₉, obtained from the root of the rauwolfia, Rauwolfia serpentina, used in the treatment of hypertension.

[1950–55; < German Reserpin=reserp- (probably irreg. < New Latin Rauwolfia serpentina (Rauwolfia rauwolfia + Late Latin serpentīna, feminine of serpentīnus serpentine¹)) + German -in -ine²]

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Noun

reserpine - antihypertensive consisting of an alkaloid extracted from the plant Rauwolfia serpentina (trade names Raudixin or Rau-Sed or Sandril or Serpasil)

Raudixin, Rau-Sed, Sandril, Serpasil

antihypertensive, antihypertensive drug - a drug that reduces high blood pressure

rauwolfia - any of several alkaloids extracted from the shrub Rauwolfia serpentina

Translations

réserpine

reserpine

n reserpina

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References in periodicals archive ?

"The CYP2D6 inhibitor ajmalicine is a member of the reserpine family of alkaloids, found in the plant Rauwolfia serpentine and was long used in India for treating mental illness, such as paranoia and schizophrenia," said Avadhani.

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History of reserpine use (4 mg/d, reduced to 1 mg/d) for unknown duration.

Botulinum toxin: Emerging psychiatric indications: Botulinum toxin has shown promising antidepressant effects, and might be helpful for several other indications

"Decades ago, physicians became aware that a medication to treat high blood pressure, reserpine, could cause severe depression.

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severe aphasia), stroke survivors on antihypertensives (like methyldopa and reserpine) that could precipitate depression and those with chronic debilitating medical conditions besides hypertension and uncomplicated diabetes.

Post-stroke depression: Prevalence, associated factors and impact on quality of life among outpatients in a Nigerian hospital

Reserpine Increases BDNF and PCNA Expression, but Decreases Caspase-3, in Rat Interstitial Cells (Leydig Cells)

La Reserpina Aumenta la Expresion de BDNF y PCNA, y Disminuye la de Caspasa-3, en Celulas Intersticiales (Celulas de Leydig) de Ratas

With the advent of pharmacotherapy like lithium in mania; chlorpromazine and reserpine in psychosis and imipramine in depression9 the rate of administration of ECT per admission in UK decreased annually from 35% in 1956 to 2.2% in 1991 and onwards8.

EFFICACY OF ELECTROCONVULSIVE THERAPY IN TREATMENT - RESISTANT DEPRESSION

The control group received normal saline (1 mg/kg, i.p.) and the reserpinized group received reserpine (5 mg kg, i.p.) 18 hours before the behavioral test.

Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression

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Briefly, mice with a rectal temperature of 36-38[degrees]C were used and randomly divided into six groups: control, reserpine (2.0 mg/kg i.p.), fluoxetine hydrochloride (15 mg/kg i.g.), curcumin (15 mg/kg i.g.), and thermoreversible gel (0.18 mg/kg, 0.36 mg/kg, and 0.72 mg/kg of curcumin via intranasal administration).

Enhancing Antidepressant Effect of Poloxamer/Chitosan Thermosensitive Gel Containing Curcumin-Cyclodextrin Inclusion Complex

Ma, "The influence of Sijunzi decoction on the pharmacokinetics of levofloxacin in rats with reserpine pretreatment," Asian Pacific Regional International Society for the Study of Xenobiotics Meeting, vol.

Preliminary Characterization of a Homogeneous Polysaccharide with Anticomplement Activity from Sijunzi Decoction

He notes, for example, that Hemingway's hypertension medicine, Reserpine, "was later shown to have significant depressive effects." Additionally, Hemingway's physician in Cuba had him on a "daily cocktail of Wychol, Ritalin, Serpasil, Equanil, and Seconal--in addition to the Reserpine." One of Hemingway's later Mayo Clinic doctors noted Ritalin and Serpasil exacerbated Hemingway's depression (242).