goitrogen

There is increased incidence of rodent thyroid tumours if TSH is elevated by goitrogen treatment.

Others suggested that suppressive effect of iodine may enhance the influence of other goitrogenic factors and increase the sensitivity of thyrocytes to TSH in iodine-deficient areas; therefore, normal TSH levels become a goitrogen [23].

Negative Influences Preventing Conversion of T4 to T3: Factors influencing the conversion of T4 to T3 include advanced age, excessive goitrogen consumption, gluten sensitivity, infectious disease, adrenal insufficiency, iodine deficiency, stress, medications, chemotherapy or radiation exposure, toxin exposure, extreme exercise, inflammation, low iron, and low testosterone.

The goitrogen 6-n-propyl-2-thiouracil (PTU) given during testis development increase sertoli germ cell numbers per cyst in fish: the tilapia (Oreochromis niloticus) model.

Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse.

Induction of increased testis growth and sperm production in adult rats by neonatal administration of the goitrogen propylthiouracil (PTU): the critical period.

Cabbage may also act as a goitrogen. It blocks organification in thyroid cells, thus inhibiting the production of the thyroid hormones (thyroxine and triiodothyronine).

Contrary to the previous observations that smoking (both active and passive) is an important goitrogen (32), there was no difference in the incidence of active and passive smoking between goitrous children and controls in our study.

The goitrogen 3-hydroxy-4(1H)-pyridone, a ruminal metabolite from Leucaena leucocepha: effects in mice and rats.

Mimosine in Leucaena leucocephala is metabolized to a goitrogen in ruminants.

However, goitrogen administration had reduced the growth rate in chicken (Rosebrough and McMurtry, 2003) and anti-thyroid axes administration resulted in decreased circulating IGF-I levels and hepatic IGF-I mRNA restorable by T4 administration (Tsukadaet al., 1998).