Pharmacotherapy comprises of
buspirone and bupropion off label treatment for HSDD in women suffering from low libido associated with anxiety and depression.
Currently, the only agent approved by the US Food and Drug Administration (FDA) is flibanserin (in premenopausal women); testosterone,
buspirone, and bupropion are all being used off-label.
Other medications that are sometimes used for anxiety include
buspirone (Buspar) and gabapentin (Neurontin).
She was diagnosed with "major depressive disorder with psychotic features." Risperidone was added to the escitalopram,
buspirone, and gabapentin that had been started by her primary care physician.
Home medications documented at the time of his arrival to the ED include sertraline, 100 mg/d, bupropion, 150 mg/d,
buspirone, 10 mg 3 times daily, diazepam 10 mg 3 times daily, as needed, adalimumab, 40 mg IM every 2 weeks, and diphenhydramine, 50 mg every night.
(14,17,18) A combination of meperidine and
buspirone has been shown to decrease the shivering threshold, but this combination has been suggested by some to potentially increase the risk of seizures with renal impairment.
Participants were 18 years or older and could not be taking any anti-anxiety medications (defined as benzodiazepines,
buspirone, SSRIs, and SNRIs), mood stabilisers, antidepressants, tranquilisers, and/or alternative therapies including herbal medicines).
Similarly, with regard to augmentation, CBT appears to work equally to augmenting initial SGA therapy with bupropion or
buspirone.
Gabapentin, pregabalin,
buspirone or even atypical antipsychotics are usually recommended for patients with anxiety disorders with a poor response to SSRIs/SNRIs.
While benzodiazepines are generally not recommended--especially in severe COPD cases due to their sedative effect on respiratory drive--alternatives such as
buspirone, tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and selective norepinephrine reuptake inhibitors (SNRIs) have been shown to effectively reduce GAD, MDD, and dyspnea in these patients (5,14 )(table (18,19)).
Using 6-OHDA-lesioned rats subjected to striatal VM grafting, significant dampening of GID (induced by amphetamine) was seen following treatment with very low doses of the 5-HT1A receptor agonist
buspirone (doses unable to affect expression of LID in the same animal model) or combination of the 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and CP94253, which all inhibit transmitter release from serotonergic neurons [34, 43].