Activity
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We’ve paid attention to models, and now I’m glad we’re paying attention to data, which is running out. We need to pay more attention to modalities…
We’ve paid attention to models, and now I’m glad we’re paying attention to data, which is running out. We need to pay more attention to modalities…
Shared by Alex Wiltschko
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Rockefeller: If you go to sleep on a win you’ll wake up with a loss “As our successes began to come, I seldom put my head upon the pillow at night…
Rockefeller: If you go to sleep on a win you’ll wake up with a loss “As our successes began to come, I seldom put my head upon the pillow at night…
Liked by Alex Wiltschko
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“Osmo will be the first to give computers a sense of smell and to achieve scent teleportation, but we certainly aren’t the first or only people to…
“Osmo will be the first to give computers a sense of smell and to achieve scent teleportation, but we certainly aren’t the first or only people to…
Liked by Alex Wiltschko
Experience & Education
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Osmo
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Publications
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Mapping Sub-Second Structure in Mouse Behavior
Neuron
Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that three-dimensional (3D) mouse pose dynamics are structured at the sub-second timescale. Computational modeling of these fast dynamics effectively describes mouse behavior as a series of reused and stereotyped modules with defined transition probabilities, which collectively encapsulate the underlying structure of…
Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that three-dimensional (3D) mouse pose dynamics are structured at the sub-second timescale. Computational modeling of these fast dynamics effectively describes mouse behavior as a series of reused and stereotyped modules with defined transition probabilities, which collectively encapsulate the underlying structure of mouse behavior within a given experiment. By deploying this 3D imaging and machine learning method in a variety of experimental contexts, we show that it unmasks potential strategies employed by the brain to generate specific adaptations to changes in the environment, and captures both predicted and previously-hidden phenotypes induced by genetic or neural manipulations. This work demonstrates that mouse body language is built from identifiable components and is organized in a predictable fashion; deciphering this language establishes an objective framework for characterizing the influence of environmental cues, genes and neural activity on behavior.
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Selective Activation of Striatal Fast-Spiking Interneurons during Choice Execution
Neuron
Striatal fast-spiking interneurons (FSIs) normally have diverse behavioral correlates ► FSI population shows a coordinated firing increase as rats initiate a chosen action ► Coordination of FSI firing may be due to divergent pallidostriatal projection ► Striatal FSIs do not produce constant strong inhibition of projection cells
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More activity by Alex
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Took a couple of weeks off to decompress and think deeply about life (see photo) - but really happy to announce that I started a new position as a…
Took a couple of weeks off to decompress and think deeply about life (see photo) - but really happy to announce that I started a new position as a…
Liked by Alex Wiltschko
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Ingredients are the very foundation of the products created by beauty and wellness brands. The innovation happening in labs around the world fuels…
Ingredients are the very foundation of the products created by beauty and wellness brands. The innovation happening in labs around the world fuels…
Liked by Alex Wiltschko
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When a technical founder eventually settles into life as a respectable middle-aged CEO. 👨💼 🥁 🎸🎤 🤘🎾
When a technical founder eventually settles into life as a respectable middle-aged CEO. 👨💼 🥁 🎸🎤 🤘🎾
Liked by Alex Wiltschko
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“Working in the interest of our national security apparatus, just as the first venture capitalists observed and designed for, is the best way to…
“Working in the interest of our national security apparatus, just as the first venture capitalists observed and designed for, is the best way to…
Liked by Alex Wiltschko
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I am officially retired from the Army as of yesterday and excited for the next chapter! Please reach out if you are a servicemember about to retire…
I am officially retired from the Army as of yesterday and excited for the next chapter! Please reach out if you are a servicemember about to retire…
Liked by Alex Wiltschko
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Osmo is hiring its first full-time marketer. If you're scent-obsessed, a natural storyteller in written, spoken, and visual form, and want to help us…
Osmo is hiring its first full-time marketer. If you're scent-obsessed, a natural storyteller in written, spoken, and visual form, and want to help us…
Shared by Alex Wiltschko
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Today marks my last day with dsm-firmenich. Every day of the past 25 years has been exciting, fulfilling and inspiring at the same time. Personal…
Today marks my last day with dsm-firmenich. Every day of the past 25 years has been exciting, fulfilling and inspiring at the same time. Personal…
Liked by Alex Wiltschko
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I got promoted to full professor! So I decided to write. And found that in addition to a lot gratitude and pride, I also have some…
I got promoted to full professor! So I decided to write. And found that in addition to a lot gratitude and pride, I also have some…
Liked by Alex Wiltschko
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The Bavarian State Chancellery plans to collaborate w/Axiom Space on space exploration activities, which includes a possible future human…
The Bavarian State Chancellery plans to collaborate w/Axiom Space on space exploration activities, which includes a possible future human…
Liked by Alex Wiltschko
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