giant platelet

A platelet that is larger than usual—e.g., the size of an RBC—a finding typical of Bernard-Soulier syndrome (BSS); up to 10% of normal platelets are ‘giant’—i.e., ‘squashed’ and oversized
DiffDx When > 20% of platelets are giant: idiopathic thromocytopaenic purpura (ITP), lymphoproliferative disorders, myeloproliferative disorders, reticulocytosis, disseminated intravascular coagulation (DIC), systemic lupus (SLE), grey platelet syndrome, May-Hegglin anomaly, type 2B von Willebrand’s disease, thrombotic thrombocytopaenic purpura (TTP)

giant platelet

A platetet that is larger than usual, a finding typical of Bernard-Soulier syndrome–BSS; up to 10% of normal platelets are 'giant', ie 'squashed' and oversized; when > 20% of platelets are giant, other conditions must be considered in addition to BSS–eg, ITP, lympho- and myeloproliferative disorders, reticulocytosis, DIC, SLE, gray platelet syndrome, May-Hegglin anomaly, Montreal platelet syndrome, TTP

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References in periodicals archive ?

Ristocetin aggregation will be abnormal in Bernard Souvelier Syndrome (Giant Platelet Syndrome).

A rare case of Glanzmann thrombasthenia

Platelet-rich plasma is an artificial milieu deficient in giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (15).

Determination of aspirin responsiveness by use of whole blood platelet aggregometry

Inherited giant platelet disorders: classification and literature review.

Thrombocytopenia

However, platelet-rich plasma is an artificial milieu deficient in giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (12).

Determination of clopidogrel resistance by whole blood platelet aggregometry and inhibitors of the [P2Y.sub.12] receptor

(28) Giant platelet disorders also have characteristic electron microscopic findings.

The laboratory diagnosis of platelet disorders: an algorithmic approach. (CAP Laboratory Improvement Programs)

Few disclaimers have to be considered while one interprets MPV in isolation: a spurious increase in MPV contributed by red blood cell fragmentation which can be counted by the analyzer as a giant platelet, a combination of hypoproductive and hyperdestructive thrombocytopenia and splenic sequestration; where large platelets are entrapped in spleen but not released into the circulation.

A retrospective evaluation of mean platelet volume as a discriminating factor in thrombocytopenia of hypoproductive and hyperdestructive aetiologies

Increased bleeding after surgery or trauma may be difficult to control.7 BSS patients shows an increased bleeding time, decreased platelets count to near normal and presence of giant platelets on peripheral smear.

Bernard Soulier Syndrome: 10 years' experience at a tertiary care hospital

Automated haematology analysers produce erroneous results in the presence of particles of similar size and shape and in the presence of giant platelets and platelet clumps.

THROMBOCYTE ESTIMATION BASED ON BLOOD SMEAR AND ITS COMPARISON USING AUTOMATED HAEMATOLOGY ANALYSERS

His platelet count was 3,321,000/[micro]L (reference range: 140,000-400,000/[micro]L) and was described as giant platelets on peripheral smear.

Takotsubo Cardiomyopathy Associated with Polycythemia Vera

Giant platelets were found in his peripheral blood smear and bone marrow aspiration showed elevated megakaryocytes with no evidence of hemophagocytosis.

Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature