Berlin Patient

Berlin Patient

A popular term for Timothy Ray Brown, a man who was infected with HIV-1 in 1995 while attending school in Berlin. He responded well to anti-retroviral therapy until 2006, when he was diagnosed with acute myeloid leukaemia. Despite an initial response to chemotherapy, he developed pneumonia and sepsis, for which a stem cell transplant was given using—instead of a matched donor—stem cells from a donor with the CCR5 mutation, which makes cells immune to HIV. Brown claims to be HIV free, which, if true, would make him the first person to have been cured of HIV.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
People who do not have CCR5, or have a mutation of it, (like the Berlin Patient and the London Patient, after their transplants) are essentially immune to HIV.
figure By JOSEPH OTHIENO In 2007, Timothy Brown, aka Berlin Patient, became the first man to be "cured" of HIV.
Timothy Ray Brown, also known as the "Berlin patient," underwent a similar procedure 12 years ago, with the same remarkable results.
The case report comes ten years after the first such case, known as the 'Berlin Patient.'
Speaking about the study, lead author Ravindra Gupta said, "By achieving remission in a second patient using a similar approach, we have shown that the Berlin Patient was not an anomaly and that it really was the treatment approaches that eliminated HIV in these two people."
This case comes 10 years after the first case, known as "Berlin Patient".
Timothy Brown, the "Berlin patient" who had similar treatment in Germany in 2007, is still HIV-free.
He added: "By achieving remission in a second patient using a similar approach, we have shown that the Berlin Patient was not an anomaly, and that it really was the treatment approaches that eliminated HIV in these two people."
Man becomes second person in world to be cleared of virus after stem cell donationALondonpatient with HIV has become the second person ever to be free of the virus after a bone marrow transplant, raising hopes of a cure for Aids.More than a decade ago, Timothy Brown, the so-called Berlin patient who later went public, made history as the first person to be "cured" of HIV.
The man is being called "the London patient", in part because his case is similar to the first known case of a functional cure of HIV - in an American man, Timothy Brown, who became known as the Berlin patient when he underwent similar treatment in Germany in 2007 which also cleared his HIV.
"By achieving remission in a second patient using a similar approach, we have shown that the Berlin Patient was not an anomaly and that it really was the treatment approaches that eliminated HIV in these two people," said Ravindra Gupta, a professor in University College London's Division of Infection and Immunity and the lead author of the study.
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